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dc.contributor.authorHoogduijn, Martin J.*
dc.contributor.authorPopp, F.*
dc.contributor.authorVerbeek, R.*
dc.contributor.authorMasoodi, Mojgan*
dc.contributor.authorNicolaou, Anna*
dc.contributor.authorBaan, C.*
dc.contributor.authorDehlke, M-H.*
dc.date.accessioned2010-12-15T11:27:00Z
dc.date.available2010-12-15T11:27:00Z
dc.date.issued2010
dc.identifier.citationHoogduijn, M. J., Popp, F., Verbeek, R. Masoodi, M., Nicolaou, A., Baan, C. and Dahlke, M.-H. (2010). The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy. International Immunopharmacology, Vol. 10, No. 12, pp.1496-1500.en
dc.identifier.urihttp://hdl.handle.net/10454/4576
dc.descriptionnoen
dc.description.abstractThere is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectMesenchymal stem cellsen
dc.subjectProstaglandinsen
dc.subjectImmunomodulationen
dc.subjectCytokinesen
dc.subjectImmune therapyen
dc.subjectOrgan transplantationen
dc.titleThe immunomodulatory properties of messenchymal stem cells and their use for immunotherapy.en
dc.status.refereedyesen
dc.typeArticleen
dc.identifier.JournalTitleInternational Immunopharmacologyen
dc.identifier.doihttps://doi.org/10.1016/j.intimp.2010.06.019


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