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    The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy.

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    Publication date
    2010
    Author
    Hoogduijn, Martin J.
    Popp, F.
    Verbeek, R.
    Masoodi, Mojgan
    Nicolaou, Anna
    Baan, C.
    Dehlke, M-H.
    Keyword
    Mesenchymal stem cells
    Prostaglandins
    Immunomodulation
    Cytokines
    Immune therapy
    Organ transplantation
    Peer-Reviewed
    yes
    
    Metadata
    Show full item record
    Abstract
    There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.
    URI
    http://hdl.handle.net/10454/4576
    Citation
    Hoogduijn, M. J., Popp, F., Verbeek, R. Masoodi, M., Nicolaou, A., Baan, C. and Dahlke, M.-H. (2010). The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy. International Immunopharmacology, Vol. 10, No. 12, pp.1496-1500.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.intimp.2010.06.019
    Type
    Article
    Collections
    Life Sciences Publications

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