The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy.
Publication date
2010Keyword
Mesenchymal stem cellsProstaglandins
Immunomodulation
Cytokines
Immune therapy
Organ transplantation
Peer-Reviewed
yes
Metadata
Show full item recordAbstract
There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.Citation
Hoogduijn, M. J., Popp, F., Verbeek, R. Masoodi, M., Nicolaou, A., Baan, C. and Dahlke, M.-H. (2010). The immunomodulatory properties of messenchymal stem cells and their use for immunotherapy. International Immunopharmacology, Vol. 10, No. 12, pp.1496-1500.Link to Version of Record
https://doi.org/10.1016/j.intimp.2010.06.019Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.intimp.2010.06.019