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dc.contributor.authorWells, G.
dc.contributor.authorSuggitt, Marie
dc.contributor.authorCoffils, M.
dc.contributor.authorBaig, M.A.H.
dc.contributor.authorHoward, P.W.
dc.contributor.authorLoadman, Paul M.
dc.contributor.authorHartley, J.A.
dc.contributor.authorJenkins, Terence C.
dc.contributor.authorThurston, D.E.
dc.date.accessioned2010-12-14T14:59:56Z
dc.date.available2010-12-14T14:59:56Z
dc.date.issued2008
dc.identifier.citationWells, G., Suggitt, M., Coffils, M., Baig, M.A.H., Howard, P.W., Loadman, P.M., Hartley, J.A., Jenkins, T.C. and Thurston, D.E. (2008). Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 6, pp. 2147-2151.en
dc.identifier.urihttp://hdl.handle.net/10454/4569
dc.descriptionnoen
dc.description.abstractThe pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a class of DNA minor groove binding agents that react covalently with guanine bases, preferably at Pu-G-Pu sites. A series of three fluorescent PBD¿coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA binding affinity, cellular localization and cytotoxicity. The results show that the linker structure plays a critical role for all three parameters. Graphical abstract A series of three fluorescent PBD¿coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA-binding affinity, cellular localization and cytotoxicity.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.bmcl.2008.01.083en
dc.subjectPyrrolobenzodiazepineen
dc.subjectPBDsen
dc.subjectDNA-bindingen
dc.subjectDNA sequence-selectiveen
dc.subjectFluorescence conjugatesen
dc.subjectNuclear penetrationen
dc.subjectAnticancer agentsen
dc.subjectAntitumour agentsen
dc.titleFluorescent 7-Diethylaminocoumarin Pyrrolobenzodiazepine conjugates: Synthesis, DNA-Interaction, Cytotoxicity and Differential Cellular Localization.en
dc.status.refereedyesen
dc.typeArticleen


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