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    The Aging Hair Pigmentary Unit

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    Publication date
    2010
    Author
    Tobin, Desmond J.
    Keyword
    Hair
    Pigmentary Unit
    Aging
    Age
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    As a highly visual and social species we communicate significantly via our physical appearance. Thus, it is unsurprising that the phenotypic aspects (including color) of our skin and hair feature prominently in such communication. Perhaps, one of the more potent reminders of aging is the change in pigmentation from birth to puberty and through to young adulthood, middle age, and beyond. Indeed, the hair bulb melanocyte may be viewed as an exquisitely sensitive aging sensor. In this context, we can appreciate that the loss of pigmentation from the hair tends to be earlier and much more striking than the age-associated pigmentation changes that we see in the epidermis. This phenotypic difference between the hair follicle and the epidermis-melanocyte subpopulations is of considerable interest, not least as both subpopulations originate from the same embyrologic neural crest and that the melanoctye stem cells in the adult hair follicle can occupy vacant niches in the epidermis. A major source of the differential aging of melanocytes in the hair bulb vs. the epidermis is likely due to the former¿s stringent coupling to the hair growth cycle when compared with the latter¿s continuous and UV-sensitive melanogenesis. Also likely to be involved is the maintenance of permissive microenvironments in these different skin compartments including their differing redox environments and variable connectivity with neuroendocrine axis. Over the last few years, we and others have striven to develop advanced cell culture methodologies for isolated hair follicle melanocytes and for intact anagen hair follicle organ culture, which may provide research tools to elucidate the regulatory mechanisms of hair follicle pigmentation. Others have assessed the robustness of the hair follicle-melanocyte stem compartment with age and other functional stressors. In the long term, it may be feasible to develop strategies to modulate some of these aging-associated changes in the hair follicle that impinge particularly of the melanocyte populations.
    URI
    http://hdl.handle.net/10454/4559
    Version
    No full-text available in the repository
    Citation
    Tobin, D.J. (2010). The Aging Hair Pigmentary Unit. In: Aging Hair. Trüeb, R.M. and Tobin, D.J. (Eds.). Heidelberg: Springer-Verlag. Pp. 77-89.
    Link to publisher’s version
    http://dx.doi.org/1007/978-3-642-02636-2_9
    Type
    Book chapter
    Collections
    Life Sciences Publications

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