Show simple item record

dc.contributor.authorRao, T.S.P.*
dc.contributor.authorSarma, N.S.*
dc.contributor.authorMurthy, Y.L.N.*
dc.contributor.authorKantamreddi, Venkata Siva Satya Narayana*
dc.contributor.authorWright, Colin W.*
dc.contributor.authorParameswaran, P.S.*
dc.date.accessioned2010-12-07T15:03:43Z
dc.date.available2010-12-07T15:03:43Z
dc.date.issued2010
dc.identifier.citationRao, T. S. P., Sarma, N. S., Murthy, Y. L. N., Kantamreddi V. S. S. N., Wright, C. W. and Parameswaran, P. S. (2010). New polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly). Tetrahedron Letters, Vol. 51, No. 27, pp. 3583-3586.en
dc.identifier.urihttp://hdl.handle.net/10454/4540
dc.descriptionnoen
dc.description.abstractFour new polyhydroxylated sterols are isolated from Marine sponge Callyspongia fibrosa collected from the Gulf of Mannar, western Bay of Bengal (India). The structural assignment is based on 1H and 13C NMR spectra. All sterols are based on the known 24S-24-methyl cholesterol 1 which is also isolated, and contain 3b,6b-dihydroxy system and 25-O-acetate as common features (except in the case of sterol 6 that has a D25 in the place of 25-OAc). Additional OH substitution is also present at 5a in 4a and at 8b in 5. A further 12b-OH is present in 6 and 7. The hydroxylation pattern is so far known only in coral sterols but is without a precedent in sponge sterols. The major steroid 4a showed antimalarial activity against Plasmodium falciparum on the chloroquine-resistant stain better than on the chloroquine-sensitive strain.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectMarine natural productsen
dc.subjectAntiplasmodialen
dc.subjectPolyhydroxy sterolsen
dc.subjectCallyspongia fibrosaen
dc.titleNew polyhydroxy sterols from the marine sponge Callyspongia fibrosa (Ridley and Dendly).en
dc.status.refereedYesen
dc.typeArticleen
dc.identifier.JournalTitleTetrahedron Letters, 51:3583-3586, 2010en
dc.type.versionNo full-text available in the repositoryen
dc.identifier.doihttps://doi.org/doi:10.1016/j.tetlet.2010.05.009


This item appears in the following Collection(s)

Show simple item record