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    Prenylated flavonoid derivatives from the bark of Erythrina addisoniae.

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    Publication date
    2008
    Author
    Watjen, W.
    Suckow-Schnitker, A-K.
    Rohrig, R.
    Kulawik, A.
    Addae-Kyereme, Jonathan A.
    Wright, Colin W.
    Passreiter, C.M.
    Keyword
    Erythrina
    Prenylated flavonoids
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Two new prenylated flavanones, 2S-3¿-(2-hydroxy-3-methylbut-3-enyl)licoflavone-4¿-methyl ether (3) and 2S-3¿-(2- hydroxy-3-methylbut-3-enyl)abyssinone II (4), and four known flavanones (1, 2, 5, 6) were isolated from the stem bark of Erythrina addisoniae. The structures were elucidated on the basis of their spectroscopic and physicochemical data. None of the compounds showed antioxidative properties. 4¿-Methylabyssinone V (1) and abyssinoflavanone VII (6) showed moderate cytotoxic activity (IC50 ) 5 and 3.5 ¿mol/L, respectively), but apoptosis (caspase-3/7-activation, nuclear fragmentation) was selectively induced by abyssinoflavanone VII (6).
    URI
    http://hdl.handle.net/10454/4532
    Version
    published version paper
    Citation
    Wätjen, W., Suckow-Schnitker, A. K., Rohrig, R., Kulawik, A., Addae-Kyereme, J., Wright, C. W. and C. M. Passreiter. (2008). Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. Journal of Natural Products. Vol. 71, No. 4, pp. 735-738.
    Link to publisher’s version
    http://dx.doi.org/10.1021/np070417j
    Type
    Article
    Collections
    Life Sciences Publications

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