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dc.contributor.authorAjaiyeoba, E.O.*
dc.contributor.authorAshidi, J.S.*
dc.contributor.authorOkpako, Larry Commander*
dc.contributor.authorHoughton, P.J.*
dc.contributor.authorWright, Colin W.*
dc.date.accessioned2010-12-07T10:24:52Z
dc.date.available2010-12-07T10:24:52Z
dc.date.issued2008
dc.identifier.citationAjaiyeoba, E. O., Ashidi, J. S., Okpako, L. C., Houghton, P. J. and Wright, C. W. (2008). Antiplasmodial compounds from Cassia siamea stem bark extract. Phytotherapy Research. Vol. 22, pp. 254¿255. doi: 10.1002/ptr.2254.en
dc.identifier.urihttp://hdl.handle.net/10454/4529
dc.descriptionnoen
dc.description.abstractCassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC50 values of 5 µg/mL, respectively.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/ptr.2254en
dc.subjectMalariaen
dc.subjectMedicinal plantsen
dc.subjectCassia siamea L. (Fabaceae)en
dc.subjectAntiplasmodial compoundsen
dc.titleAntiplasmodial compounds from Cassia siamea stem bark extract.en
dc.status.refereedyesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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