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    Antiplasmodial compounds from Cassia siamea stem bark extract.

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    Publication date
    2008
    Author
    Ajaiyeoba, E.O.
    Ashidi, J.S.
    Okpako, Larry Commander
    Houghton, P.J.
    Wright, Colin W.
    Keyword
    Malaria
    Medicinal plants
    Cassia siamea L. (Fabaceae)
    Antiplasmodial compounds
    Peer-Reviewed
    yes
    
    Metadata
    Show full item record
    Abstract
    Cassia siamea L. (Fabaceae) was identified from the southwest Nigerian ethnobotany as a remedy for febrile illness. This led to the bioassay-guided fractionation of stem bark of the plant extract, using the parasite lactate dehydrogenase assay and multi-resistant strain of Plasmodium falciparum (K1) for assessing the in vitro antimalarial activity. Emodin and lupeol were isolated from the ethyl acetate fraction by a combination of chromatographic techniques. The structures of the compounds were determined by spectroscopy, co-spotting with authentic samples and comparison with literature data. Both compounds were found to be the active principles responsible for the antiplasmodial property with IC50 values of 5 µg/mL, respectively.
    URI
    http://hdl.handle.net/10454/4529
    Version
    No full-text available in the repository
    Citation
    Ajaiyeoba, E. O., Ashidi, J. S., Okpako, L. C., Houghton, P. J. and Wright, C. W. (2008). Antiplasmodial compounds from Cassia siamea stem bark extract. Phytotherapy Research. Vol. 22, pp. 254¿255. doi: 10.1002/ptr.2254.
    Link to publisher’s version
    http://dx.doi.org/10.1002/ptr.2254
    Type
    Article
    Collections
    Life Sciences Publications

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