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dc.contributor.advisorRandall, Valerie A.
dc.contributor.advisorThornton, M. Julie
dc.contributor.authorZemaryalai, Khatera
dc.date.accessioned2010-11-05T16:49:22Z
dc.date.available2010-11-05T16:49:22Z
dc.date.issued2010-11-05T16:49:22Z
dc.identifier.urihttp://hdl.handle.net/10454/4461
dc.description.abstractHair disorders cause significant distress. The main, but limited, treatment for hair loss is minoxidil, an ATP-­sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in human hair follicles. To expand our understanding, the red deer hair follicle model was used initially. Deer follicles expressed the same KATP channel genes as human follicles when growing (anagen), but no channels were detected in resting follicles. This reinforces the importance of KATP channels in active hair growth and the usefulness of the deer model. To assess whether SUR1 KATP channels are actually involved in human hair growth, the effects of a selective SUR1 channel opener, NNC55-­9216, on scalp follicle growth in organ culture was examined. NNC55-­9216 stimulated anagen; its effect was augmented by minoxidil. This creates the potential for more effective pharmaceuticals to treat hair loss via SUR1 channels, either alone or in combination with minoxidil. The dermal papilla plays a crucial regulatory role in hair follicle activity determining the type of hair produced. Minoxidil had no effect on dermal papilla cell proliferation, but altered the profile of proteins produced when assessed by proteomics. Further research into the roles of KATP channels and greater understanding of the significance of these protein changes should enhance our knowledge of hair biology and help the development of new, improved therapies for hair pathologies.en
dc.language.isoenen
dc.rights© 2010 Zemaryalai, K. This work is licensed under a Creative Commons Attribution-Non-Commercial-Share-Alike License (http://creativecommons.org/licenses/by-nc-nd/2.0/uk).en
dc.subjectHair folliclesen
dc.subject; Humanen
dc.subject; KATP channelen
dc.subject; Minoxidilen
dc.subject; Animal modelen
dc.subject; Red deeren
dc.subject; SUR1en
dc.subject; SUR2Ben
dc.subject; Dermal papillaen
dc.subject; Hair lossen
dc.titleInvestigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-­sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.en
dc.type.qualificationleveldoctoralen
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentDepartment of Biomedical Sciencesen
dc.typeThesiseng
dc.type.qualificationnamePhDen
dc.date.awarded2010
refterms.dateFOA2018-07-19T04:15:29Z


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