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dc.contributor.advisorShaw, G.
dc.contributor.authorHildick, Brian G.*
dc.date.accessioned2010-07-23T14:14:32Z
dc.date.available2010-07-23T14:14:32Z
dc.date.issued2010-07-23T14:14:32Z
dc.identifier.urihttp://hdl.handle.net/10454/4400
dc.description.abstractSome compounds, analogous to those found in naturally occurring systems, are found to possess chemotherapeutic activity. Some, in the form of their nucleoside or nucleotide derivatives, are valuable antimetabolites in that they may block normal RNA or DNA polymerisation, or may be incorporated into nucleic acids to form fraudulent, but not necessarily defective, polymers. Modification of natural ring systems, with a view to promoting chemotherapeutic activity is therefore of considerable interest; variation in the position and nature of the modification or ring substituent having a marked effect on chemotherapeutic activity. It is the purpose of this thesis to suggest methods for the facile synthesis of various uracils, pyrazoles and pyrazolo [3,4-d] - pyrimidines with alkyl, aryl and glycosyl substituents such that the nature of the ring substituents is easily varied. To this end a number of ethoxymethylene reagents were prepared which, by reaction with primary amines and hydrazines, would give acyclic intermediates capable of easy cyclisation into the uracil, pyrazole and pyrazolo [3,4-d] pyrimidine ring systems. Variation in the nature of specific substituents being determined by the choice of amine or hydrazine, other substituents being varied by modification of the original reagent.en
dc.description.sponsorshipS.R.G.en
dc.language.isoenen
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.en
dc.subjectPyrimidinesen
dc.subjectImidazolesen
dc.subjectPurinesen
dc.subjectChemical synthesisen
dc.subjectPyrazolesen
dc.subjectPyrazolo pyrimidinesen
dc.subjectChemotherapeutic activityen
dc.titleStudies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.en
dc.type.qualificationleveldoctoralen
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentBoard of Physical Sciencesen
dc.typeThesiseng
dc.type.qualificationnamePhDen
dc.date.awarded1978
refterms.dateFOA2018-10-24T01:18:10Z


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