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    Comparison of coping, quality of life and psychosocial well-being in children and adult patients with vitiligo before and after treatment with pseudocatalase PC-KUS. A questionnaire-based investigation into social anxiety, helplessness, anxious-depressive mood, quality of life and depression before and after treatment with pseudocatalase PC-KUS depending on demographic characteristics and experiences.

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    Publication date
    2010-05-25T10:09:24Z
    Author
    Krüger, Christian
    Supervisor
    Schallreuter, Karin U.
    Keyword
    Vitiligo
    Quality of life
    Social anxiety
    Avoidance
    Helplessness
    Anxious / depressive mood
    Depigmentation
    Depression
    Anxiety
    Children
    Adults
    Pseudocatalase PC-KUS
    Treatment
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    Rights
    Creative Commons License
    The University of Bradford theses are licenced under a Creative Commons Licence.
    Institution
    University of Bradford
    Department
    Division of Biomedical Sciences, School of Life Sciences.
    Awarded
    2009
    
    Metadata
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    Abstract
    Vitiligo is an idiopathic, non-contagious and often familial depigmentation disorder affecting both sexes equally. The mostly progressive and patchy loss of the inherited skin colour is not only a cosmetical problem, it has a profound impact on the patient¿s well-being. Stigmatisation and rejection often causes depression, self-consciousness, sexual problems and an impaired quality of life. To further substantiate earlier investigations and to introduce new aspects, we utilised the Dermatology Life Quality Index (DLQI), the Beck Depression Inventory (BDI) and the Adjustment to Chronic Skin Disorders Questionnaire (ACS) with its sub-scales on Social anxiety / avoidance, Helplessness and Anxious-depressive Mood in 422 patients and 55 healthy controls. We also included 103 children, their parents and 18 controls by using the Children¿s Dermatology Life Quality Index (CDLQI) and an adapted version of the ACS. We found that patients with vitiligo experience high levels of stigmatisation. They have an impaired quality of life and are more socially anxious / avoidant, helpless and (anxious-) depressive compared to healthy controls. The results correlate with disease severity, avoidant behaviour / hiding of vitiligo and the belief that psychological stress influences the disease. Female patients are generally more affected. Treatment with pseudocatalase PC-KUS improves quality of life and reduces anxious-depressive mood. Children also suffer from stigmatisation and an impaired quality of life. Parents are more socially anxious and helpless compared to the control group.
    URI
    http://hdl.handle.net/10454/4313
    Type
    Thesis
    Qualification name
    PhD
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