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The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique

dc.contributor.authorRowe, Raymond C.*
dc.contributor.authorColbourn, E.A.*
dc.contributor.authorRoskilly, S.J.*
dc.contributor.authorYork, Peter*
dc.date.accessioned2009-12-17T13:43:00Z
dc.date.available2009-12-17T13:43:00Z
dc.date.issued2005
dc.identifier.citationRowe, R., Colbourn, E.A., Roskilly, S.J. and York, P. (2005). The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique. International Journal of Pharmaceutics. Vol. 300, No. 1-2, pp. 32-37.
dc.identifier.urihttp://hdl.handle.net/10454/4127
dc.descriptionNo
dc.description.abstractA computer simulation based on a Monte-Carlo technique has been developed and used to investigate the influence of pellet size, dispersity, shape and aggregation on the filling of hard shell capsules. The simulations are in general agreement with experimental observations previously reported. The results also confirm recent findings that filling is a function of pellet shape and that above an aspect ratio value of 1.2 filling reproducibility is reduced. The methodology is simple and rapid in execution allowing many computer-based experiments to be performed with minimum effort.
dc.language.isoen
dc.subjectPellets
dc.subjectCapsule Filling
dc.subjectComputer Simulation
dc.subjectMonte-Carlo
dc.titleThe influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2005.05.007
dc.openaccess.statusclosedAccess


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