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    The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique

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    Publication date
    2005
    Author
    Rowe, Raymond C.
    Colbourn, E.A.
    Roskilly, S.J.
    York, Peter
    Keyword
    Pellets
    Capsule Filling
    Computer Simulation
    Monte-Carlo
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    A computer simulation based on a Monte-Carlo technique has been developed and used to investigate the influence of pellet size, dispersity, shape and aggregation on the filling of hard shell capsules. The simulations are in general agreement with experimental observations previously reported. The results also confirm recent findings that filling is a function of pellet shape and that above an aspect ratio value of 1.2 filling reproducibility is reduced. The methodology is simple and rapid in execution allowing many computer-based experiments to be performed with minimum effort.
    URI
    http://hdl.handle.net/10454/4127
    Version
    No full-text available in the repository
    Citation
    Rowe, R., Colbourn, E.A., Roskilly, S.J. and York, P. (2005). The influence of pellet shape, size and distribution on capsule filling - A preliminary evaluation of three-dimensional computer simulation using a Monte-Carlo technique. International Journal of Pharmaceutics. Vol. 300, No. 1-2, pp. 32-37.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.ijpharm.2005.05.007
    Type
    Article
    Collections
    Life Sciences Publications

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