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dc.contributor.authorBlagden, Nicholas*
dc.contributor.authorBooth, S.W.*
dc.contributor.authorDe Matos, Luciana L.*
dc.contributor.authorWilliams, Adrian C.*
dc.date.accessioned2009-12-17T10:17:36Z
dc.date.available2009-12-17T10:17:36Z
dc.date.issued2007
dc.identifier.citationBlagden, N., Booth, S.W., DeMatos, L.L. and Williams, A.C. (2007). Solvent influences on Metastable Polymorph Lifetimes:Real-time interconversions using Energy Dispersive X-Ray Diffractometry. Journal of Pharmaceutical Sciences. Vol. 96, No. 5, pp. 1069-1078.en
dc.identifier.urihttp://hdl.handle.net/10454/4120
dc.descriptionNoen
dc.description.abstractSolvent influences on the crystallization of polymorph and hydrate forms of the nootropic drug piracetam (2-oxo-pyrrolidineacetamide) were investigated from water, methanol, 2-propanol, isobutanol, and nitromethane. Crystal growth profiles of piracetam polymorphs were constructed using time-resolved diffraction snapshots collected for each solvent system. Measurements were performed by in situ energy dispersive X-ray diffraction recorded in Station 16.4 at the synchrotron radiation source (SRS) at Daresbury Laboratory, CCLRC UK. Crystallizations from methanol, 2-propanol, isobutanol, and nitromethane progressed in a similar fashion with the initial formation of form I which then converted relatively quickly to form II with form III being generated upon further cooling. However, considerable differences were observed for the polymorphs lifetime and both the rate and temperature of conversion using the different solvents. The thermodynamically unstable form I was kinetically favored in isobutanol and nitromethane where traces of this polymorph were observed below 10°C. In contrast, the transformation of form II and subsequent growth of form III were inhibited in 2-propanol and nitromethane solutions. Aqueous solutions produced hydrate forms of piracetam which are different from the reported monohydrate; this crystallization evolved through successive generation of transient structures which transformed upon exchange of intramolecular water between the liquid and crystalline phasesen
dc.language.isoenen
dc.subjectPolymorphen
dc.subjectSynchrotronen
dc.subjectHydrateen
dc.subjectTransformationen
dc.subjectCrystal Growthen
dc.subjectPiracetamen
dc.subjectIn Situ Crystallisationen
dc.subjectSolvent Effectsen
dc.subjectEnergy Dispersive X-ray Diffractionen
dc.titleSolvent influences on Metastable Polymorph Lifetimes:Real-time interconversions using Energy Dispersive X-Ray Diffractometryen
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen
dc.identifier.doihttps://doi.org/10.1002/jps.20924


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