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    Prostaglandin production by melanocytic cells and the effect of a-melanocyte stimulating hormone

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    Publication date
    2004
    Author
    Nicolaou, Anna
    Estdale, Siân E.
    Tsatmali, Marina
    Herrero, Daniel Pascual
    Thody, Anthony J.
    Keyword
    Prostaglandin; FM55; Melanocytic Cell; Cyclooxygenase; HaCaT; a-Melanocyte Stimulating Hormone
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Prostaglandins are potent mediators of the inflam-matory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and-2) and thus have the capability to produce prostaglandins. TheFM55 cells produced predominantly PGE2and PGF2a, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inflammatory peptide, a-melanocyte stimulating hormone(a-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine TNF-a in the former. These results indicate that melanocytes produce prostaglandins and that a-MSH, by inhibiting this response, may play an important role in regulating inflammatory responses in the skin.
    URI
    http://hdl.handle.net/10454/4098
    Version
    No full-text available in the repository
    Citation
    Nicolaou A, Estdale SE, Tsatmali M, Herrero DP and Thody AJ (2004). Prostaglandin production by melanocytic cells and the effect of melanocyte stimulating hormone. FEBS Letters. 570(1-3): 223-226.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.febslet.2004.06.041
    Type
    Article
    Collections
    Life Sciences Publications

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