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dc.contributor.authorLisgarten, J.N.*
dc.contributor.authorColl, M.*
dc.contributor.authorPortugal, J.*
dc.contributor.authorWright, Colin W.*
dc.contributor.authorAymami, J.*
dc.date.accessioned2009-12-09T16:51:28Z
dc.date.available2009-12-09T16:51:28Z
dc.date.issued2001
dc.identifier.citationLisgarten, J. N., Coll, M., Portugal, J., Wright, C. W. and Aymami, J. (2001). The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. Nature Structural Biology, Vol. 9, pp. 57 - 60.en
dc.identifier.urihttp://hdl.handle.net/10454/4045
dc.descriptionnoen
dc.description.abstractCryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)2 in a base-stacking intercalation mode.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.isreferencedbyhttp://www.dx.doi.org/10.1038/nsb729en
dc.subjectCryptolepineen
dc.subjectIndoloquinoline alkaloiden
dc.subjectAntimalarial drugsen
dc.subjectDNA intercalationen
dc.titleThe antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionpublished version paperen


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