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    Fragmentation of N-linked glycans with a matrix-assisted laser desorption/ionization ion trap time-of-flight mass spectrometer.

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    Publication date
    2004
    Author
    Harvey, D.J.
    Martin, R.L.
    Jackson, K.A.
    Sutton, Chris W.
    Keyword
    N-linked glycans
    Matrix-assisted laser desorption
    MS3 spectra
    Ion trap
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    N-Linked glycans were ionized from several matrices with a Shimadzu-Biotech AXIMA-QIT matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometer. [M+Na]+ ions were produced from all matrices and were accompanied by varying amounts of in-source fragmentation products. The least fragmentation was produced by 2,5-dihydroxybenzoic acid and the most by -cyano-4-hydroxycinnamic acid and 6-aza-2-thiothymine. Sialic acid loss was extensive but could be prevented by formation of methyl esters. Fragmentation produced typical low-energy-type spectra dominated by ions formed by glycosidic cleavages. MSn spectra (n = 3 and 4) were used to probe the pathways leading to the major diagnostic ions. Thus, for example, an ion that was formed by loss of the core GlcNAc residues and the 3-antenna was confirmed as being formed by a B/Y rather than a C/Z mechanism. The proposed structures of several cross-ring cleavage ions were confirmed and it was shown that MS3 spectra could be obtained from as little as 10 fmol of glycan
    URI
    http://hdl.handle.net/10454/4039
    Version
    published version paper
    Citation
    Harvey, D.J., Martin R.L., Jackson, K.A., Sutton, C.W. (2004). Rapid Commununications in Mass Spectrometry. Vol. 18, No. 24, pp. 2997-3007.
    Link to publisher’s version
    http://dx.doi.org/10.1002/rcm.1709
    Type
    Article
    Collections
    Life Sciences Publications

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