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    Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids

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    Publication date
    2009-12-07T16:13:04Z
    Author
    Urquhart, Paula
    Parkin, Susan M.
    Nicolaou, Anna
    Keyword
    Human saphenous vein
    Endothelial cells
    Endothelial metabolism
    N-3 polyunsaturated fatty acids
    Dietary fatty acids
    Eicosapentaenoic acid
    Docosahexaenoic acid
    Prostaglandin F2 ¿(PGF2 ¿).
    Thromboxane
    Calcium
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Human saphenous vein endothelial cells (HSVECs) derived from primary cultures of adult human veins constitute an excellent in vitro model for studying human endothelial metabolism. In this study we report the14C-labelled prostanoid profile of HSVECs under resting and stimulated conditions and the effect of the n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid on them. Results indicate that HSVECs while under resting conditions produce mainly prostaglandin F2 ¿(PGF2 ¿). After stimulation with calcium ionophore A23187, the cells were found to synthesise PGI2, PGE2and PGF2¿as major products and thromboxane B2and PGD2as minor products. Production of14C-labelled hydroxyeicosatetraenoic acids was not detected. Eicosapentaenoic acid was found to inhibit basal and stimulated prostanoid production whereas docosahexaenoic acid inhibited basal but strongly increased stimulated prostanoid production. These results may offer the basis for further studies aiming to investigate targets for pharmacological intervention in inflammatory conditions.
    URI
    http://hdl.handle.net/10454/4038
    Version
    published version paper
    Citation
    Urquhart, P., Parkin, S. M. and Nicolaou, A. (2001). Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 65, No. 1, pp. 15-22.
    Link to publisher’s version
    http://dx.doi.org/10.1054/plef.2001.0282
    Type
    Article
    Collections
    Life Sciences Publications

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