Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.
|dc.contributor.author||Forbes, Robert T.|
|dc.contributor.author||Edwards, Anthony D.|
|dc.contributor.author||Shekunov, Boris Yu.|
|dc.identifier.citation||Edwards, A.D., Shekunov. B.Y., Grossman, G.J. and York, P. (2001). Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine. Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1106-1114.||en|
|dc.description.abstract||The thermodynamic status of -carbamazepine has been clarified using equilibrium solubility measurements, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), heated X-ray powder diffraction (XRPD), and temperature-controlled X-ray scattering techniques. -Carbamazepine is the least stable of the three well-characterized anhydrous polymorphs of carbamazepine at 25°C. In addition, it was confirmed that -carbamazepine undergoes an exothermic transition to -carbamazepine at 130°C. The novel technique of time-resolved simultaneous small- and wide-angle X-ray scattering has been successfully applied to monitor this transition in situ. It was concluded that -carbamazepine has a monotropic relationship with -carbamazepine.||en|
|dc.title||Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.||en|
|dc.type.version||No full-text available in the repository||en|