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dc.contributor.authorForbes, Robert T.*
dc.contributor.authorEdwards, Anthony D.*
dc.contributor.authorShekunov, Boris Yu.*
dc.contributor.authorGrossmann, J,*
dc.contributor.authorYork, Peter*
dc.date.accessioned2009-11-30T14:59:43Z
dc.date.available2009-11-30T14:59:43Z
dc.date.issued2001
dc.identifier.citationEdwards, A.D., Shekunov. B.Y., Grossman, G.J. and York, P. (2001). Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine. Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1106-1114.en
dc.identifier.urihttp://hdl.handle.net/10454/4018
dc.descriptionNoen
dc.description.abstractThe thermodynamic status of -carbamazepine has been clarified using equilibrium solubility measurements, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), heated X-ray powder diffraction (XRPD), and temperature-controlled X-ray scattering techniques. -Carbamazepine is the least stable of the three well-characterized anhydrous polymorphs of carbamazepine at 25°C. In addition, it was confirmed that -carbamazepine undergoes an exothermic transition to -carbamazepine at 130°C. The novel technique of time-resolved simultaneous small- and wide-angle X-ray scattering has been successfully applied to monitor this transition in situ. It was concluded that -carbamazepine has a monotropic relationship with -carbamazepine.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org///10.1002/jps.1064en
dc.subjectCrystallizationen
dc.subjectNomenclatureen
dc.subjectPhysical stabilityen
dc.subjectPolymorphismen
dc.titleTime-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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