Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine.
dc.contributor.author | Forbes, Robert T. | * |
dc.contributor.author | Edwards, Anthony D. | * |
dc.contributor.author | Shekunov, Boris Yu. | * |
dc.contributor.author | Grossmann, J, | * |
dc.contributor.author | York, Peter | * |
dc.date.accessioned | 2009-11-30T14:59:43Z | |
dc.date.available | 2009-11-30T14:59:43Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Edwards, A.D., Shekunov. B.Y., Grossman, G.J. and York, P. (2001). Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine. Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1106-1114. | en |
dc.identifier.uri | http://hdl.handle.net/10454/4018 | |
dc.description | No | en |
dc.description.abstract | The thermodynamic status of -carbamazepine has been clarified using equilibrium solubility measurements, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), heated X-ray powder diffraction (XRPD), and temperature-controlled X-ray scattering techniques. -Carbamazepine is the least stable of the three well-characterized anhydrous polymorphs of carbamazepine at 25°C. In addition, it was confirmed that -carbamazepine undergoes an exothermic transition to -carbamazepine at 130°C. The novel technique of time-resolved simultaneous small- and wide-angle X-ray scattering has been successfully applied to monitor this transition in situ. It was concluded that -carbamazepine has a monotropic relationship with -carbamazepine. | en |
dc.language.iso | en | en |
dc.subject | Crystallization | en |
dc.subject | Nomenclature | en |
dc.subject | Physical stability | en |
dc.subject | Polymorphism | en |
dc.title | Time-resolved x-ray scattering using synchrotron radiation applied to the study of a polymorphic transition in carbamazepine. | en |
dc.status.refereed | Yes | en |
dc.type | Article | en |
dc.type.version | No full-text available in the repository | en |
dc.identifier.doi | https://doi.org///10.1002/jps.1064 |