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dc.contributor.authorEdwards, Anthony D.*
dc.contributor.authorShekunov, Boris Yu.*
dc.contributor.authorKordikowski, Andreas*
dc.contributor.authorForbes, Robert T.*
dc.contributor.authorYork, Peter*
dc.date.accessioned2009-11-25T08:37:54Z
dc.date.available2009-11-25T08:37:54Z
dc.date.issued2001
dc.identifier.citationEdwards, A.D., Shekunov, B.Y., Kordikowski, A., Forbes, R.T. and York, P (2001). Crystallisation of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS¿). Journal of Pharmaceutical Sciences. Vol. 90, No. 8, pp. 1115-1124.en
dc.identifier.urihttp://hdl.handle.net/10454/3977
dc.descriptionNoen
dc.description.abstractPure anhydrous polymorphs of carbamazepine were prepared by solution-enhanced dispersion with supercritical fluids (SEDSTM). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDSTM process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. -Carbamazepine was crystallized at high supersaturations and low temperatures, -carbamazepine crystallized from a methanol-carbon dioxide phase split, and -carbamazepine crystallized via nucleation at high temperatures and low supersaturation.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/jps.1065en
dc.subjectCrystallizationen
dc.subjectSEDSen
dc.subjectDispersionen
dc.subjectPolymorphismen
dc.titleCrystallisation of pure anhydrous polymorphs of carbamazepine by solution enhanced dispersion with supercritical fluids (SEDS¿).en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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