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dc.contributor.authorSchechter, L.E.*
dc.contributor.authorDawson, L.A.*
dc.contributor.authorHarder, Josie A.*
dc.date.accessioned2009-11-16T12:30:03Z
dc.date.available2009-11-16T12:30:03Z
dc.date.issued2002
dc.identifier.citationSchechter, L.E., Dawson, L.A. and Harder, J.A. (2002). The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer s disease. Current Pharmaceutical Design. Vol. 8, No. 2, pp. 139-145.en
dc.identifier.urihttp://hdl.handle.net/10454/3925
dc.descriptionNoen
dc.description.abstractThe 5-HT1A receptor has been extensively studied over the last two decades. There is a plethora of information describing its anatomical, physiological and biochemical roles in the brain. In addition, the development of selective pharmacological tools coupled with our understanding of psychiatric pathology has lead to multiple hypotheses for the therapeutic utility of 5- and in particular 5-HT1A receptor antagonists. Over the last decade it has been suggested that 5-HT1A receptor antagonists may have therapeutic utility in such diseases as depression, anxiety, drug and nicotine withdrawal as well as schizophrenia. However, a very compelling rationale has been developed for the therapeutic potential of 5-HT1A receptor antagonists in Alzheimer s disease and potentially other diseases with associated cognitive dysfunction. Receptor blockade by a 5-HT1A receptor antagonist appears to enhance activation and signaling through heterosynaptic neuronal circuits known to be involved in cognitive processes and, as such, represents a novel therapeutic approach to the treatment of cognitive deficits associated with Alzheimer s disease and potentially other disorders with underlying cognitive dysfunction.en
dc.language.isoenen
dc.subject5-HT1A receptor antagonistsen
dc.subjectHT1A agentsen
dc.subjectAlzheimer s diseaseen
dc.subjectCognitive dysfunctionen
dc.titleThe potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer s disease.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen
dc.identifier.doihttps://doi.org/10.2174/1381612023396483


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