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    The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer s disease.

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    Publication date
    2002
    Author
    Schechter, L.E.
    Dawson, L.A.
    Harder, Josie A.
    Keyword
    5-HT1A receptor antagonists
    HT1A agents
    Alzheimer s disease
    Cognitive dysfunction
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The 5-HT1A receptor has been extensively studied over the last two decades. There is a plethora of information describing its anatomical, physiological and biochemical roles in the brain. In addition, the development of selective pharmacological tools coupled with our understanding of psychiatric pathology has lead to multiple hypotheses for the therapeutic utility of 5- and in particular 5-HT1A receptor antagonists. Over the last decade it has been suggested that 5-HT1A receptor antagonists may have therapeutic utility in such diseases as depression, anxiety, drug and nicotine withdrawal as well as schizophrenia. However, a very compelling rationale has been developed for the therapeutic potential of 5-HT1A receptor antagonists in Alzheimer s disease and potentially other diseases with associated cognitive dysfunction. Receptor blockade by a 5-HT1A receptor antagonist appears to enhance activation and signaling through heterosynaptic neuronal circuits known to be involved in cognitive processes and, as such, represents a novel therapeutic approach to the treatment of cognitive deficits associated with Alzheimer s disease and potentially other disorders with underlying cognitive dysfunction.
    URI
    http://hdl.handle.net/10454/3925
    Version
    No full-text available in the repository
    Citation
    Schechter, L.E., Dawson, L.A. and Harder, J.A. (2002). The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer s disease. Current Pharmaceutical Design. Vol. 8, No. 2, pp. 139-145.
    Link to publisher’s version
    http://dx.doi.org/10.2174/1381612023396483
    Type
    Article
    Collections
    Life Sciences Publications

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