Truncated azinomycin analogues intercalate into DNA.
| dc.contributor.author | Casely-Hayford, M.A. | * |
| dc.contributor.author | Pors, Klaus | * |
| dc.contributor.author | Patterson, Laurence H. | * |
| dc.contributor.author | Gerner, C. | * |
| dc.contributor.author | Neidle, S. | * |
| dc.contributor.author | Searcey, M. | * |
| dc.date.accessioned | 2009-11-16T07:49:49Z | |
| dc.date.available | 2009-11-16T07:49:49Z | |
| dc.date.issued | 2005 | |
| dc.identifier.citation | Casely-Hayward, M., Pors, K., Patterson, L.H. and Gerner, C. et al. (2005). Truncated azinomycin analogues intercalate into DNA. Bioorganic Medicinal Chemistry Letters. Vol. 15, No. 3, pp. 653-656. | |
| dc.identifier.uri | http://hdl.handle.net/10454/3908 | |
| dc.description | No | |
| dc.description.abstract | The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. Graphical abstract A designed analogue of the left half of azinomycin has been synthesized and unwinds supercoiled DNA. | |
| dc.language.iso | en | |
| dc.subject | Azinomycin | |
| dc.subject | Intercalation | |
| dc.subject | DNA unwinding | |
| dc.subject | Synthesis | |
| dc.subject | Analogues | |
| dc.title | Truncated azinomycin analogues intercalate into DNA. | |
| dc.status.refereed | Yes | |
| dc.type | Article | |
| dc.type.version | No full-text in the repository | |
| dc.identifier.doi | https://doi.org/10.1016/j.bmcl.2004.11.037 | |
| dc.openaccess.status | closedAccess |