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    Truncated azinomycin analogues intercalate into DNA.

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    Publication date
    2005
    Author
    Casely-Hayford, M.A.
    Pors, Klaus
    Patterson, Laurence H.
    Gerner, C.
    Neidle, S.
    Searcey, M.
    Keyword
    Azinomycin
    Intercalation;
    DNA unwinding
    Synthesis
    Analogues
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. Graphical abstract A designed analogue of the left half of azinomycin has been synthesized and unwinds supercoiled DNA.
    URI
    http://hdl.handle.net/10454/3908
    Version
    No full-text available in the repository
    Citation
    Casely-Hayward, M., Pors, K., Patterson, L.H. and Gerner, C. et al. (2005). Truncated azinomycin analogues intercalate into DNA. Bioorganic Medicinal Chemistry Letters. Vol. 15, No. 3, pp. 653-656.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.bmcl.2004.11.037
    Type
    Article
    Collections
    Life Sciences Publications

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