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    Effects of the classical antipsychotic haloperidol and atypical anti-psychotic risperidone on weight gain, the oestrous cycle and uterine weight in female rats.

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    Publication date
    2004
    Author
    Fell, M.J.
    Neill, Joanna C.
    Marshall, Kay M.
    Keyword
    Antipsychotics
    Haloperidol
    Risperidone
    Weight gain
    Sexual dysfunction;
    Side effects
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Antipsychotic drug-induced side effects of weight gain and sexual dysfunction have clinical significance adversely affecting both compliance and morbidity. This study evaluated the effects of haloperidol and the atypical antipsychotic risperidone (0.1¿1.0 mg/kg) on weight gain, food and water intake, the oestrous cycle and uterine weight in female hooded Lister rats. Haloperidol and risperidone treated rats displayed marked weight gain, although only risperidone induced significant increases in food consumption over the 21-day period. Neither haloperidol nor risperidone influenced water consumption. Marked disruption of the oestrous cycle was observed in risperidone- and haloperidol-treated animals (0.5 and 1.0 mg/kg), which was supported by significantly reduced uterine weights. The findings presented here suggest that the weight gain and sexual dysfunction induced by antipsychotics may be modelled in rodents. This model may offer insight into the mechanisms involved in mediation of such side effects.
    URI
    http://hdl.handle.net/10454/3872
    Version
    No full-text available in the repository
    Citation
    Fell, M.J., Neill, J.C. and Marshall, K.M. (2004). Effects of the classical antipsychotic haloperidol and atypical anti-psychotic risperidone on weight gain, the oestrous cycle and uterine weight in female rats. European Neuropsychopharmacology. Vol. 14, No. 5, pp. 385-392.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.euroneuro.2003.12.001
    Type
    Article
    Collections
    Life Sciences Publications

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