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    Effect of the oestrous cycle, pregnancy and uterine region on the responsiveness of the isolated mouse uterus to prostaglandin F(2alpha) and the thromboxane mimetic U46619.

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    Publication date
    2009-11-03T15:11:26Z
    Author
    Griffiths, A.L.
    Marshall, Kay M.
    Senior, J.
    Fleming, C.
    Woodward, D.F.
    Keyword
    Oestrus cycle
    Pregnancy
    Uterine region
    Prostaglandins F(2alpha)
    Thromboxane mimetic U46619
    Peer-Reviewed
    Yes
    
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    Abstract
    Previous studies in this laboratory have suggested that the isolated uterus from non-pregnant mice has a prostaglandin F and a thromboxane receptor population similar to that found in human myometrium. The aim of this study was to investigate any regional variation in myogenic activity ) and the and responsiveness to prostaglandin F(2alpha) (PGF(2alpha) thromboxane mimetic U46619 in the mouse uterus taken during different stages of the oestrous cycle and during pregnancy. Uterine samples from BKW mice were taken from different anatomical segments along the length of each uterine horn and set up for superfusion at 2 ml/min with Krebs solution (containing 1 microM indometacin) at 37 degrees C, and gassed with 95%O(2)/5%CO(2). Responses (area under the curve) are expressed as a percentage of the final contraction induced by hypotonic shock. Data are expressed as the means +/- s.e.m. of n=5-12 and were analysed using Student's paired t-test or two-way ANOVA with a Bonferroni post hoc test. Regional variation in myogenic activity was observed in all tissues studied except those taken during labour. These tissues displayed significantly greater myogenic activity than tissues taken at late gestation and at all stages of the oestrous cycle. Tissues from pregnant animals were generally more responsive to U46619 and PGF(2alpha) than tissues taken from non-pregnant animals. Tissues taken from the upper segment of the uterine horn were more responsive to both agonists during the oestrous cycle. The findings demonstrated that the hormonal milieu and site of excision are important for myogenic activity and responsiveness.
    URI
    http://hdl.handle.net/10454/3841
    Version
    No full-text available in the repository
    Citation
    Griffiths, A.L., Marshall, K.M., Senior, J., Fleming, C. and, Woodward, D.F. (2006). Effect of the oestrous cycle, pregnancy and uterine region on the responsiveness of the isolated mouse uterus to prostaglandin F(2alpha) and the thromboxane mimetic U46619. Journal of Endocrinology. Vol. 188, No. 3, pp. 569-577.
    Link to publisher’s version
    http://dx.doi.org/10.1677/joe.1.06466
    Type
    Article
    Collections
    Life Sciences Publications

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