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    The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus.

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    Publication date
    2006
    Author
    Javid, Farideh A.
    Naylor, Robert J.
    Keyword
    Motion sickness
    8-OH-DPAT
    Suncus murinus
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    In the present study we evaluated the role of 5-HT1A receptors in mediating the inhibitory action of 8-OH-DPAT, a 5-HT1A receptor agonist, in motion sickness in Suncus murinus. 8-OH-DPAT (0.1 mg/kg, i. p) attenuated motion-induced emesis which was associated with an increase in the latency of the onset to the first emetic episode. Pre-treatment with methysergide (a 5-HT1/2/7 receptor antagonist, 1.0 mg/kg, i. p.), WAY-100635 (a 5-HT1A receptor antagonist, 1.0 mg/kg, i. p.), SB269970A (a 5-HT7 receptor antagonist, 1.0 and 5.0 mg/kg, i. p.), ondansetron (a 5-HT3 receptor antagonist, 1.0 mg/kg, i. p) or GR13808 (a 5-HT4 receptor antagonist, 0.5 mg/kg, i. p) failed to modify the inhibitory action of 8-OH-DPAT on motion sickness. Furthermore, the application of either methysergide, WAY-100635, SB269970A, ondansetron or GR13808 alone had no effect on motion sickness in its own right. These data indicate that neither 5-HT1A nor any 5-HT2 receptor subtypes, 5-HT3, 5-HT4 and 5-HT7 receptors are likely to be involved in the inhibition of motion-induced emesis mediated by 8-OH-DPAT.
    URI
    http://hdl.handle.net/10454/3765
    Version
    No full-text available in the repository
    Citation
    Javid, F. and Naylor, R.J. (2006). The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus. Pharmacology Biochemistry and Behavior. Vol. 85, No. 4, pp. 820-826.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.pbb.2006.11.018
    Type
    Article
    Collections
    Life Sciences Publications

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