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    Electroporation and ultradeformable liposomes; human skin barrier repair by phospholipid.

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    Publication date
    2003
    Author
    Essa, Ebtessam A.
    Bonner, Michael C.
    Barry, Brian W.
    Keyword
    Electroporation
    Liposomes
    Phospholipid
    Human skin
    Estradiol
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    This work investigated the effect of electroporation on human epidermal penetration of a model neutral lipophilic compound (estradiol) from saturated aqueous solution and when encapsulated in ultradeformable liposomes. Total amount penetrated and skin deposition were compared with values obtained from passive diffusion. The effect of electrical pulsing on liposome size was investigated. The action of phosphatidylcholine on skin that was structurally altered by such pulses was determined. Electroporation did not affect liposome size. Skin pulsing considerably increased estradiol penetration and skin deposition from solution, relative to passive delivery, with subsequent partial recovery of skin resistance to molecular penetration. Surprisingly, with liposomes, electroporation did not markedly affect estradiol skin penetration. Importantly, liposomal phosphatidylcholine applied during or after pulsing accelerated skin barrier repair, i.e. provided an anti-enhancer or retardant effect.
    URI
    http://hdl.handle.net/10454/3763
    Version
    No full-text available in the repository
    Citation
    Essa, E.A., Bonner, M.C. and Barry, B.W. (2003). Electroporation and ultradeformable liposomes; human skin barrier repair by phospholipid. Journal of Controlled Release. Vol. 92, No. 1-2, pp. 163-172.
    Link to publisher’s version
    http://dx.doi.org/10.1016/S0168-3659(03)00326-2
    Type
    Article
    Collections
    Life Sciences Publications

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