Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery.
Abstract
A series of lipoamino acid-based glycolipids were synthesised. Suitably derivatised lipoamino acid derivatives were prepared and conjugated to monosaccharides (including glycosyl azides, isothiocyanates, thiols and sulphones) to yield novel O-, N-, S- and C-linked glycolipids in good yields. Their potential to improve the oral absorption of piperacillin is reported.Version
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Falconer, R.A. and Toth, I. (2007). Design, Synthesis and Biological Evaluation ofnovel lipoamino acid-based glycolipids for oral drug delivery. Bioorganic & Medicinal Chemistry. Vol. 15, No. 22, pp. 7012-7020.Link to Version of Record
https://doi.org/10.1016/j.bmc.2007.07.048Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.bmc.2007.07.048