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dc.contributor.authorMammukari, C.*
dc.contributor.authorTommasi di Vignano, A.*
dc.contributor.authorSharov, A.A.*
dc.contributor.authorNeilson, J.*
dc.contributor.authorHavrda, M.C.*
dc.contributor.authorRoop, D.R.*
dc.contributor.authorBotchkarev, Vladimir A.*
dc.contributor.authorCrabtree, G.R.*
dc.contributor.authorPaolo Dotto, G*
dc.date.accessioned2009-10-13T14:01:28Z
dc.date.available2009-10-13T14:01:28Z
dc.date.issued2005
dc.identifier.citationMammukari, C., Tommasi di Vignano, A., Sharov, A. A., Neilson, J. and Botchkarev, V.A. et al. (2005). Integration of Notch1 and calcineurin/NFAT signaling pathway in keratinocyte growth and differentiation control. Developmental Cell. Vol. 8, No. 5, pp. 665-676.en
dc.identifier.urihttp://hdl.handle.net/10454/3660
dc.descriptionNoen
dc.description.abstractThe Notch and Calcineurin/NFAT pathways have both been implicated in control of keratinocyte differentiation. Induction of the p21WAF1/Cip1 gene by Notch 1 activation in differentiating keratinocytes is associated with direct targeting of the RBP-J¿ protein to the p21 promoter. We show here that Notch 1 activation functions also through a second Calcineurin-dependent mechanism acting on the p21 TATA box-proximal region. Increased Calcineurin/NFAT activity by Notch signaling involves downregulation of Calcipressin, an endogenous Calcineurin inhibitor, through a HES-1-dependent mechanism. Besides control of the p21 gene, Calcineurin contributes significantly to the transcriptional response of keratinocytes to Notch 1 activation, both in vitro and in vivo. In fact, deletion of the Calcineurin B1 gene in the skin results in a cyclic alopecia phenotype, associated with altered expression of Notch-responsive genes involved in hair follicle structure and/or adhesion to the surrounding mesenchyme. Thus, an important interconnection exists between Notch 1 and Calcineurin-NFAT pathways in keratinocyte growth/differentiation control.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.devcel.2005.02.016en
dc.subjectDevelopmenten
dc.subjectRegulation(control)en
dc.subjectDifferentiationen
dc.subjectGrowthen
dc.subjectKeratinocyteen
dc.subjectSignal transductionen
dc.subjectCalcineurinen
dc.titleIntegration of Notch1 and calcineurin/NFAT signaling pathway in keratinocyte growth and differentiation control.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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