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dc.contributor.authorKauser, Sobia*
dc.contributor.authorThody, Anthony J.*
dc.contributor.authorSchallreuter, Karin U.*
dc.contributor.authorTobin, Desmond J.*
dc.contributor.authorGummer, C.L.*
dc.date.accessioned2009-10-05T13:22:30Z
dc.date.available2009-10-05T13:22:30Z
dc.date.issued2004
dc.identifier.citationKauser, S., Thody, A.J., Schallreuter, K.U. and Tobin, D.J. et al. (2004). beta-Endorphin as a regulator of human hair follicle melanocyte biology. Journal of Investigative Dermatology. Vol. 123, No. 1, pp. 184-195.en
dc.identifier.urihttp://hdl.handle.net/10454/3606
dc.descriptionNoen
dc.description.abstractThe pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulatory role also exists for the endogenous opiate, -endorphin (-END). A role for this -END in the regulation of follicular pigmentation, however, has not been determined. This study was designed to examine the involvement of the -END/-opiate receptor system in human follicular melanocyte biology. We employed RT-PCR, and immunohisto/cytochemistry and immunoelectron microscopy using -END and -opiate receptor specific antibodies and a functional role for -END was assessed by direct stimulation with the peptide. This study has demonstrated that human hair follicle melanocytes (HFM) express mRNA for the -opiate receptor and POMC. Furthermore, -END and its high affinity -opiate receptor are expressed at the protein level in glycoprotein100-positive follicular melanocytes and as a function of their anatomic location and differentiation status during the hair growth cycle. Functional studies revealed that -END is a modifier of HFM phenotype via its ability to upregulate melanogenesis, dendricity, and proliferation. These findings suggest a new regulatory role for -END in human HFM biology, providing a new research direction into the fundamental regulation of human hair pigmentation.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1111/j.0022-202X.2004.22724.xen
dc.subjectDendricityen
dc.subjectHair pigmentation,en
dc.subjectMelanogenesisen
dc.subjectOpiate receptoren
dc.titlebeta-Endorphin as a regulator of human hair follicle melanocyte biology.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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