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    beta-Endorphin as a regulator of human hair follicle melanocyte biology.

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    Publication date
    2004
    Author
    Kauser, Sobia
    Thody, Anthony J.
    Schallreuter, Karin U.
    Tobin, Desmond J.
    Gummer, C.L.
    Keyword
    Dendricity
    Hair pigmentation,
    Melanogenesis
    Opiate receptor
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The pro-opiomelanocortin (POMC)-derived peptides, -melanocyte-stimulating hormone, and adrenocorticotropic hormone, are important mediators of human skin pigmentation via action at the melanocortin-1 receptor. Recent data suggests that such a regulatory role also exists for the endogenous opiate, -endorphin (-END). A role for this -END in the regulation of follicular pigmentation, however, has not been determined. This study was designed to examine the involvement of the -END/-opiate receptor system in human follicular melanocyte biology. We employed RT-PCR, and immunohisto/cytochemistry and immunoelectron microscopy using -END and -opiate receptor specific antibodies and a functional role for -END was assessed by direct stimulation with the peptide. This study has demonstrated that human hair follicle melanocytes (HFM) express mRNA for the -opiate receptor and POMC. Furthermore, -END and its high affinity -opiate receptor are expressed at the protein level in glycoprotein100-positive follicular melanocytes and as a function of their anatomic location and differentiation status during the hair growth cycle. Functional studies revealed that -END is a modifier of HFM phenotype via its ability to upregulate melanogenesis, dendricity, and proliferation. These findings suggest a new regulatory role for -END in human HFM biology, providing a new research direction into the fundamental regulation of human hair pigmentation.
    URI
    http://hdl.handle.net/10454/3606
    Version
    No full-text available in the repository
    Citation
    Kauser, S., Thody, A.J., Schallreuter, K.U. and Tobin, D.J. et al. (2004). beta-Endorphin as a regulator of human hair follicle melanocyte biology. Journal of Investigative Dermatology. Vol. 123, No. 1, pp. 184-195.
    Link to publisher’s version
    http://dx.doi.org/10.1111/j.0022-202X.2004.22724.x
    Type
    Article
    Collections
    Life Sciences Publications

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