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dc.contributor.authorSharov, A.A.*
dc.contributor.authorWeiner, L.*
dc.contributor.authorSharova, T.Y.*
dc.contributor.authorSiebenhaar, F.*
dc.contributor.authorAtoyan, R.*
dc.contributor.authorReginato, A.M.*
dc.contributor.authorMcNamara, C.A.*
dc.contributor.authorFuna, K.*
dc.contributor.authorGilchrest, B.A.*
dc.contributor.authorBrissette, J.L.*
dc.contributor.authorBotchkarev, Vladimir A.*
dc.date.accessioned2009-10-05T08:43:23Z
dc.date.available2009-10-05T08:43:23Z
dc.date.issued2003
dc.identifier.citationSharov AA, Weiner L, Sharova TY, et al (2003) Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. The EMBO Journal. 22 (12): 2992-3003.en
dc.identifier.urihttp://hdl.handle.net/10454/3595
dc.descriptionNoen
dc.description.abstractContact of developing sensory organs with the external environment is established via the formation of openings in the skin. During eye development, eyelids first grow, fuse and finally reopen, thus providing access for visual information to the retina. Here, we show that eyelid opening is strongly inhibited in transgenic mice overexpressing the bone morphogenetic protein (BMP) antagonist noggin from the keratin 5 (K5) promoter in the epidermis. In wild-type mice, enhanced expression of the kinase-inactive form of BMPR-IB mediated by an adenovirus vector also inhibits eyelid opening. Noggin overexpression leads to reduction of apoptosis and retardation of cell differentiation in the eyelid epithelium, which is associated with downregulation of expression of the apoptotic receptors (Fas, p55 kDa TNFR), Id3 protein and keratinocyte differentiation markers (loricrin, involucrin). BMP-4, but not EGF or TGF-, accelerates opening of the eyelid explants isolated from K5-Noggin transgenic mice when cultured ex vivo. These data suggest that the BMP signaling pathway plays an important role in regulation of genetic programs of eyelid opening and skin remodeling during the final steps of eye morphogenesis.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1093/emboj/cdg291en
dc.subjectFasen
dc.subjectInvolucrinen
dc.subjectLoricrinen
dc.subjectp55TNFRen
dc.subjectSkinen
dc.titleNoggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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