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    Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.

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    Publication date
    2003
    Author
    Sharov, A.A.
    Weiner, L.
    Sharova, T.Y.
    Siebenhaar, F.
    Atoyan, R.
    Reginato, A.M.
    McNamara, C.A.
    Funa, K.
    Gilchrest, B.A.
    Brissette, J.L.
    Botchkarev, Vladimir A.
    Show allShow less
    Keyword
    Fas
    Involucrin
    Loricrin
    p55TNFR
    Skin
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Contact of developing sensory organs with the external environment is established via the formation of openings in the skin. During eye development, eyelids first grow, fuse and finally reopen, thus providing access for visual information to the retina. Here, we show that eyelid opening is strongly inhibited in transgenic mice overexpressing the bone morphogenetic protein (BMP) antagonist noggin from the keratin 5 (K5) promoter in the epidermis. In wild-type mice, enhanced expression of the kinase-inactive form of BMPR-IB mediated by an adenovirus vector also inhibits eyelid opening. Noggin overexpression leads to reduction of apoptosis and retardation of cell differentiation in the eyelid epithelium, which is associated with downregulation of expression of the apoptotic receptors (Fas, p55 kDa TNFR), Id3 protein and keratinocyte differentiation markers (loricrin, involucrin). BMP-4, but not EGF or TGF-, accelerates opening of the eyelid explants isolated from K5-Noggin transgenic mice when cultured ex vivo. These data suggest that the BMP signaling pathway plays an important role in regulation of genetic programs of eyelid opening and skin remodeling during the final steps of eye morphogenesis.
    URI
    http://hdl.handle.net/10454/3595
    Version
    No full-text available in the repository
    Citation
    Sharov AA, Weiner L, Sharova TY, et al (2003) Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. The EMBO Journal. 22 (12): 2992-3003.
    Link to publisher’s version
    http://dx.doi.org/10.1093/emboj/cdg291
    Type
    Article
    Collections
    Life Sciences Publications

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