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dc.contributor.authorAtkinson, Jennifer M.*
dc.contributor.authorGill, Jason H.*
dc.contributor.authorLoadman, Paul M.*
dc.contributor.authorMartin, Sandie W.*
dc.contributor.authorPennington, J.*
dc.contributor.authorAnikin, V.A.*
dc.contributor.authorMearns, A.J.*
dc.contributor.authorEdwards, D.R.*
dc.date.accessioned2009-09-23T08:42:41Z
dc.date.available2009-09-23T08:42:41Z
dc.date.issued2007
dc.identifier.citationAtkinson, J.M., Gill, J.H., Loadman, P.M. and Martin, S.W. et al. (2007). Membrane Type MMPs Show Differential Expression in Non-Small Cell Lung Cancer (NSCLC) Compared to Normal Lung; Correlation of MMP-14 mRNA Expression and Proteolytic Activity. European Journal of Cancer. Vol. 43, No. 11, pp. 1764-1771.en
dc.identifier.urihttp://hdl.handle.net/10454/3494
dc.descriptionNoen
dc.description.abstractImproved understanding of the involvement of matrix metalloproteinases (MMPs), including membrane-type MMPs (MT-MMPs), in human tumours has potential diagnostic, prognostic and therapeutic implications. We assessed the relationship between MT-MMP expression and clinicopathological parameters in human non-small cell lung cancer (NSCLC) and histologically normal lung tissue by quantitative Real Time PCR (qRT-PCR). All MT-MMPs (MMPs 14-17, 24 and 25) were detected by qRT-PCR with significantly higher MMP-14, -15 and -17 expression observed in tumour relative to normal lung specimens. MMP-16 was undetectable in normal lung but expressed in 8% tumours. MMP-15 demonstrated significant overexpression in adenocarcinomas relative to squamous cell carcinomas and normal lung tissue. MMP-14 mRNA expression strongly correlated to MMP-14 proteolytic activity in preclinical tumour models, indicating that qRT-PCR may predict MMP-14 activity levels in NSCLC. These data suggest that MMP-14, -15 and -17 may be good markers of disease, or therapeutic targets for treatment of human NSCLC.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.ejca.2007.05.009en
dc.subjectMembrane-type metalloproteinasesen
dc.subjectLung canceren
dc.subjectReal-time PCRen
dc.subjectCarcinomaen
dc.subjectNon-small cell lungen
dc.subjectCancer therapeuticsen
dc.titleMembrane Type MMPs Show Differential Expression in Non-Small Cell Lung Cancer (NSCLC) Compared to Normal Lung; Correlation of MMP-14 mRNA Expression and Proteolytic Activity.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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