Show simple item record

dc.contributor.authorKauser, Sobia*
dc.contributor.authorThody, Anthony J.*
dc.contributor.authorSchallreuter, Karin U.*
dc.contributor.authorGummer, C.L.*
dc.contributor.authorTobin, Desmond J.*
dc.date.accessioned2009-09-15T10:58:18Z
dc.date.available2009-09-15T10:58:18Z
dc.date.issued2005
dc.identifier.citationKauser, S., Thody, A.J., Schallreuter, K.U. and Gummer, C.L. et al. (2005). A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology. Vol. 146, No. 2, pp. 532-543.en
dc.identifier.urihttp://hdl.handle.net/10454/3456
dc.descriptionNoen
dc.description.abstractThe proopiomelanocortin (POMC)-derived peptides, ACTH and alpha-MSH, are the principal mediators of human skin pigmentation via their action at the melanocortin-1 receptor (MC-1R). Recent data have demonstrated the existence of a functionally active beta-endorphin/mu-opiate receptor system in both epidermal and hair follicle melanocytes, whereby beta-endorphin can regulate melanogenesis, dendricity, and proliferation in these cells. However, a role for ACTH and alpha-MSH in the regulation of the human follicular pigmentary unit has not been determined. This study was designed to examine the involvement of ACTH and the alpha-MSH/MC-1R system in human follicular melanocyte biology. To address this question we employed RT-PCR and immunohisto/cytochemistry, and a functional role for these POMC peptides was assessed in follicular melanocyte cultures. Human scalp hair follicle melanocytes synthesized and processed POMC. ACTH and alpha-MSH in association with their processing enzymes and MC-1R are expressed in human follicular melanocytes at the message level in vitro and at the protein level both in situ and in vitro. The expression of the POMC/MC-1R receptor system was confined only to subpopulations of poorly and moderately differentiated melanocytes. In addition, functional studies revealed that ACTH and alpha-MSH are able to promote follicular melanocyte differentiation by up-regulating melanogenesis, dendricity, and proliferation in less differentiated melanocyte subpopulations. Thus, these findings suggest a role for these POMC peptides in regulating human hair follicle melanocyte differentiation.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1210/en.2004-1145en
dc.subjectPOMC-derived peptidesen
dc.subjectSkin pigmentsen
dc.subjectHuman scalp hair folliclesen
dc.subjectACTHen
dc.subjectMSHen
dc.titleA fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


This item appears in the following Collection(s)

Show simple item record