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    A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes.

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    Publication date
    2005
    Author
    Kauser, Sobia
    Thody, Anthony J.
    Schallreuter, Karin U.
    Gummer, C.L.
    Tobin, Desmond J.
    Keyword
    POMC-derived peptides
    Skin pigments
    Human scalp hair follicles
    ACTH
    MSH
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The proopiomelanocortin (POMC)-derived peptides, ACTH and alpha-MSH, are the principal mediators of human skin pigmentation via their action at the melanocortin-1 receptor (MC-1R). Recent data have demonstrated the existence of a functionally active beta-endorphin/mu-opiate receptor system in both epidermal and hair follicle melanocytes, whereby beta-endorphin can regulate melanogenesis, dendricity, and proliferation in these cells. However, a role for ACTH and alpha-MSH in the regulation of the human follicular pigmentary unit has not been determined. This study was designed to examine the involvement of ACTH and the alpha-MSH/MC-1R system in human follicular melanocyte biology. To address this question we employed RT-PCR and immunohisto/cytochemistry, and a functional role for these POMC peptides was assessed in follicular melanocyte cultures. Human scalp hair follicle melanocytes synthesized and processed POMC. ACTH and alpha-MSH in association with their processing enzymes and MC-1R are expressed in human follicular melanocytes at the message level in vitro and at the protein level both in situ and in vitro. The expression of the POMC/MC-1R receptor system was confined only to subpopulations of poorly and moderately differentiated melanocytes. In addition, functional studies revealed that ACTH and alpha-MSH are able to promote follicular melanocyte differentiation by up-regulating melanogenesis, dendricity, and proliferation in less differentiated melanocyte subpopulations. Thus, these findings suggest a role for these POMC peptides in regulating human hair follicle melanocyte differentiation.
    URI
    http://hdl.handle.net/10454/3456
    Version
    No full-text available in the repository
    Citation
    Kauser, S., Thody, A.J., Schallreuter, K.U. and Gummer, C.L. et al. (2005). A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology. Vol. 146, No. 2, pp. 532-543.
    Link to publisher’s version
    http://dx.doi.org/10.1210/en.2004-1145
    Type
    Article
    Collections
    Life Sciences Publications

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