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dc.contributor.authorSunkersett, Mohit R.*
dc.contributor.authorGrimsey, Ian M.*
dc.contributor.authorDoughty, Stephen W.*
dc.contributor.authorOsburn, John C.*
dc.contributor.authorYork, Peter*
dc.contributor.authorRowe, Raymond C.*
dc.date.accessioned2009-09-15T09:12:00Z
dc.date.available2009-09-15T09:12:00Z
dc.date.issued2001
dc.identifier.citationSunkersett, M.R., Grimsey, I.M., Doughty, S.W. and York, P. et al. (2001). The Changes In Surface Energetics With Relative Humidity Of Carbamazepine And Paracetamol As Measured By Inverse Gas Chromatography. European Journal of Pharmaceutical Sciences. Vol. 13, No. 2, pp. 219-225.en
dc.identifier.urihttp://hdl.handle.net/10454/3453
dc.descriptionNoen
dc.description.abstractThe surface energetic parameters of carbamazepine and paracetamol have been studied using inverse gas chromatography modified to produce dry and ambient conditions within the column. The values of the dispersive component of the surface free energy (¿DS) do not change significantly at the increased relative humidity. In contrast the specific component of the free energy of adsorption (-¿GSPA) as measured by polar probes, can either remain constant or decrease by up to 10%, depending on the material and the probe. This indicates that an increase in the relative humidity causes a decrease in the surface energetics of the powder surface. It is proposed that where the water molecules are adsorbing to the same sites as the polar probes, the interaction of these probes with the surface is decreased. To identify these sites, the preferential interaction of each probe, including water, with the drug molecule has been modelled.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/S0928-0987(01)00105-1en
dc.subjectParacetamolen
dc.subjectCarbamazepineen
dc.subjectAnalgesicen
dc.subjectAnticonvulsanten
dc.subjectRelative humidityen
dc.subjectSurface energyen
dc.subjectFree energyen
dc.subjectGas chromatographyen
dc.subjectMolecular interactionen
dc.subjectAdsorptionen
dc.subjectTricyclic compounden
dc.subjectDibenzazepine derivativesen
dc.subjectSorptionen
dc.subjectModelingen
dc.titleThe Changes In Surface Energetics With Relative Humidity Of Carbamazepine And Paracetamol As Measured By Inverse Gas Chromatography.en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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