The Changes In Surface Energetics With Relative Humidity Of Carbamazepine And Paracetamol As Measured By Inverse Gas Chromatography.
Publication date
2001Author
Sunkersett, Mohit R.Grimsey, Ian M.
Doughty, Stephen W.
Osburn, John C.
York, Peter
Rowe, Raymond C.
Keyword
ParacetamolCarbamazepine
Analgesic
Anticonvulsant
Relative humidity
Surface energy
Free energy
Gas chromatography
Molecular interaction
Adsorption
Tricyclic compound
Dibenzazepine derivatives
Sorption
Modeling
Peer-Reviewed
YesOpen Access status
closedAccess
Metadata
Show full item recordAbstract
The surface energetic parameters of carbamazepine and paracetamol have been studied using inverse gas chromatography modified to produce dry and ambient conditions within the column. The values of the dispersive component of the surface free energy (¿DS) do not change significantly at the increased relative humidity. In contrast the specific component of the free energy of adsorption (-¿GSPA) as measured by polar probes, can either remain constant or decrease by up to 10%, depending on the material and the probe. This indicates that an increase in the relative humidity causes a decrease in the surface energetics of the powder surface. It is proposed that where the water molecules are adsorbing to the same sites as the polar probes, the interaction of these probes with the surface is decreased. To identify these sites, the preferential interaction of each probe, including water, with the drug molecule has been modelled.Version
No full-text in the repositoryCitation
Sunkersett, M.R., Grimsey, I.M., Doughty, S.W. and York, P. et al. (2001). The Changes In Surface Energetics With Relative Humidity Of Carbamazepine And Paracetamol As Measured By Inverse Gas Chromatography. European Journal of Pharmaceutical Sciences. Vol. 13, No. 2, pp. 219-225.Link to Version of Record
https://doi.org/10.1016/S0928-0987(01)00105-1Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/S0928-0987(01)00105-1