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dc.contributor.advisorEdwards, Howell G.M.
dc.contributor.authorAli, H.R.H.*
dc.date.accessioned2009-08-21T15:14:17Z
dc.date.available2009-08-21T15:14:17Z
dc.date.issued2009-08-21T15:14:17Z
dc.identifier.urihttp://hdl.handle.net/10454/3343
dc.description.abstractThe aim of this work was to assess the suitability of vibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticals. Budesonide, fluticasone propionate, salbutamol hemisulfate, terbutaline hemisulfate, ipratropium bromide, polymorphic forms of salmeterol xinafoate and two polymorphic forms of sulfathiazole were selected since they are used in the management of certain respiratory disorders and from different chemical and pharmacological entities along with some pharmaceutical excipients. Conventional visual examination is not sufficient to identify and differentiate spectra between different pharmaceuticals. To confirm the assignment of key molecular vibrational band signatures, quantum chemical calculations of the vibrational spectra were employed for better understanding of the first five selected drugs. The nondestructive nature of the vibrational spectroscopic techniques and the success of quantum chemical calculations demonstrated in this work have indeed offered a new dimension for the rapid identification and characterisation of pharmaceuticals and essentially warrant further research. The application of simultaneous in situ Raman spectroscopy and differential scanning calorimetry for the preliminary investigation of the polymorphic transformation of salmeterol xinafoate polymorphs and two polymorphic forms of sulfathiazole has also been explored in this work leading to the development of a new method for the solid-state estimation of the transition temperature of entantiotropically related pharmaceutical polymorphs which represents the first analytical record of the use of this approach for pharmaceutical polymorphs.en
dc.language.isoenen
dc.rights© 2009 Ali, HRH. This work is licensed under a Creative Commons Attribution-Non-Commercial-Share-Alike License (http://creativecommons.org/licenses/by-nc-nd/2.0/uk).en
dc.subjectRamanen
dc.subject; IRen
dc.subject; NIRen
dc.subject; DSCen
dc.subject; Quantum chemical calculationsen
dc.subject; Pharmaceuticalsen
dc.subject; Excipientsen
dc.subject; Polymorphsen
dc.subject; Solid-stateen
dc.subject; In-situ Ramen spectroscopyen
dc.subject; Pharmaceutical analysisen
dc.subject; Drugsen
dc.titleVibrational spectroscopic techniques (Raman, FT-IR and FT-NIR spectroscopy) as a means for the solid-state structural analysis of pharmaceuticalsen
dc.type.qualificationleveldoctoralen
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentSchool of Pharmacyen
dc.typeThesiseng
dc.type.qualificationnamePhDen
dc.date.awarded2009
refterms.dateFOA2018-07-18T14:06:33Z


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