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    cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide

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    Publication date
    2007
    Author
    Graham, Anne M.
    Naseem, Khalid M.
    Oberprieler, Nikolaus G.
    Riba, Rocio
    Roberts, Wayne
    Homer-Vanniasinkam, Shervanthi
    Keyword
    Nitric oxide
    cGMP
    Platelets
    Integrin ¿IIbß3
    Tyrosine phosphorylation
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    We examined the influence of S-nitrosoglutathione (GSNO) on alpha(IIb)beta(3) integrin-mediated platelet adhesion to immobilised fibrinogen. GSNO induced a time- and concentration-dependent inhibition of platelet adhesion. Inhibition was cGMP-independent and associated with both reduced platelet spreading and protein tyrosine phosphorylation. To investigate the cGMP-independent effects of NO we evaluated integrin beta(3) phosphorylation. Adhesion to fibrinogen induced rapid phosphorylation of beta(3) on tyrosines 773 and 785, which was reduced by GSNO in a cGMP independent manner. Similar results were observed in suspended platelets indicating that NO-induced effects were independent of spreading-induced signalling. This is the first demonstration that NO directly regulates integrin beta(3) phosphorylation.
    URI
    http://hdl.handle.net/10454/3313
    Version
    No full-text available in the repository
    Citation
    Oberprieler, N.G., Roberts, W., Riba, R., Graham, A.M., Naseem, K.M. and Homer-Vanniasinkam, S. (2007). cGMP-independent inhibition of integrin alphaIIbbeta3- mediated platelet adhesion and outside-in signalling by nitric oxide. FEBS Letters. Vol. 581, No. 7, pp. 1529-34.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.febslet.2007.02.072
    Type
    Article
    Collections
    Life Sciences Publications

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