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dc.contributor.authorAssi, Khaled H.
dc.contributor.authorChrystyn, Henry
dc.contributor.authorTarsin, W.
dc.date.accessioned2009-07-31T14:17:32Z
dc.date.available2009-07-31T14:17:32Z
dc.date.issued2006
dc.identifier.citationAssi, K.H., Tarsin, W. and Chrystyn, H. (2006). High Performance Liquid Chromatography Assay Method for Simultaneous Quantitation of Formoterol and Budesonide in Symbicort Turbuhaler. Journal of Pharmaceutical and Biomedical Analysis. Vol. 41, No. 1, pp. 325-328.en
dc.identifier.urihttp://hdl.handle.net/10454/3205
dc.descriptionNoen
dc.description.abstractA sensitive and rapid high performance liquid chromatography method has been developed and used for the simultaneous determination of formoterol and budesonide in Symbicort Turbuhaler when assessing the aerodynamic characteristics of the emitted dose using Pharmacopoeial methods. This capability results in both time and cost saving. The mobile phase composition was acetonitrile-5 mM sodium dihydrogen orthophosphate, pH 3 (60: 40% v/v), and was passed at 1.5 ml min-1 through a C18 column with a UV detection (wavelength 214 nm). The method was shown to give good analytical performance in terms of linearity, precision (using phenylpropanolamine as an internal standard), sensitivity and solution stability. The intra-day precision for both formoterol and budesonide were 0.75% and 1.11%, respectively (n = 10). The limit of quantitation for formoterol was 10 ¿g L-1 and for budesonide was 120 ¿g L-1, and the limit of detection were 3 and 30 ¿g L-1, for both formoterol and budesonide, respectively. The method has been applied to determine the content of the emitted dose and the fine particle dose of Symbicort Turbuhaler.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.jpba.2005.11.015en
dc.subjectSimultaneous measurementen
dc.subjectHPLC chromatographyen
dc.subjectCorticosteroiden
dc.subjectß-Adrenergic receptor agonisten
dc.subjectß2-Adrenergic receptoren
dc.subjectAgonisten
dc.subjectAntiinflammatory agenten
dc.subjectBronchodilatoren
dc.subjectAntiasthma agenten
dc.subjectBudesonideen
dc.subjectFormoterolen
dc.titleHigh Performance Liquid Chromatography Assay Method for Simultaneous Quantitation of Formoterol and Budesonide in Symbicort Turbuhaleren
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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