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dc.contributor.authorPors, Klaus*
dc.contributor.authorPaniwnyk, Z.*
dc.contributor.authorPatterson, Laurence H.*
dc.contributor.authorRuparelia, K.C.*
dc.contributor.authorHartley, J.A.*
dc.contributor.authorKelland, L.R.*
dc.date.accessioned2009-07-28T08:13:30Z
dc.date.available2009-07-28T08:13:30Z
dc.date.issued2004
dc.identifier.citationPors,K., Paniwnyk, Z., Ruparelia, K.C., Teesdale-Spittle, P.H., Hartley, J.A., Kelland, L.R. and Patterson, L.H. (2004). Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells. Journal of Medicinal Chemistry. Vol. 47, No. 7, pp. 1856-1859.en
dc.identifier.urihttp://hdl.handle.net/10454/3164
dc.descriptionNoen
dc.description.abstractNovel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective hydroxyethylaminoanthraquinone intermediates were synthesized. Selected chloroethylaminoanthraquinones were shown to cross-link DNA and alkylate guanines (at low nM concentration) with a preference for reaction sites containing 5'-PyG. A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alkylated but did not cross-link DNA. All the 1,4-disubstituted chloroethylaminoanthraquinones were potently cytotoxic (nM IC50s) against cisplatin-resistant ovarian cancer cell lines.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1021/jm031070uen
dc.subjectPlatinum II Complexesen
dc.subjectAlkylating agenten
dc.subjectOrganic chlorine compoundsen
dc.subjectDiamineen
dc.subjectAromatic amineen
dc.subjectQuinoneen
dc.subjectAnthraquinone derivativesen
dc.subjectChemical synthesisen
dc.subjectOvaryen
dc.subjectHumanen
dc.subjectCell lineen
dc.subjectIn vitroen
dc.subjectCisplatinen
dc.subjectTumor cellen
dc.subjectResistanceen
dc.subjectCytotoxicityen
dc.subjectAntineoplastic agenten
dc.subjectStructure activity relationen
dc.titleSynthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cellsen
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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