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    Modulation of the cytotoxicity and geno-toxicity of the drinking water disinfection by-product iodoacetic acid by suppression of oxidative stress 

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    Publication date
    2006
    Author
    Anderson, Diana
    Cemeli, Eduardo
    Richardson, S.D.
    Wagner, E.D.
    Plewa, M.J.
    Keyword
    Cytooxicity
    Geno-toxicity
    Drinking water
    Disinfection
    Iodoacetic acid
    Oxidative stress
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Drinking water disinfection byproducts (DBPs) are generated by the chemical disinfection of water and may pose a hazard to the public health. Previously we demonstrated that iodoacetic acid was the most cytotoxic and genotoxic DBP analyzed in a mammalian cell system. Little is known of the mechanisms of its genotoxicity. The involvement of oxidative stress in the toxicity of iodoacetic acid was analyzed with the antioxidants catalase and butylated hydroxyanisole (BHA). Iodoacetic acid toxicity was quantitatively measured with and without antioxidants in Salmonella typhimurium strain TA100 and with Chinese hamster ovary (CHO) cells. The endpoints included cytotoxicity in S. typhimurium or in CHO cells, mutagenicity in S. typhimurium, and genotoxicity in CHO cells. Neither catalase nor BHA reduced the level of iodoacetic acid induced cytotoxicity in S. typhimurium. In CHO cells neither antioxidant caused a significant reduction in iodoacetic acid induced cytotoxicity. However, in S. typhimurium, BHA or catalase reduced the mutagenicity of iodoacetic acid by 33.5 and 26.8%, respectively. Likewise, BHA or catalase reduced iodoacetic acid induced genomic DNA damage by 86.5 and 42%, respectively. These results support the hypothesis that oxidative stress is involved in the induction of genotoxicity and mutagenicity by iodoacetic acid.
    URI
    http://hdl.handle.net/10454/3161
    Version
    No full-text available in the repository
    Citation
    Cemeli, E., Wagner, E.D., Anderson, D., Richardson, S.D. and Plewa, M.J. (2006). Modulation of the cytotoxicity and geno-toxicity of the drinking water disinfection by-product iodoacetic acid by suppression of oxidative stress. Environmental Science & Technology. Vol. 40, No. 6, pp. 1878-1883.
    Link to publisher’s version
    http://dx.doi.org/10.1021/es051602r
    Type
    Article
    Collections
    Life Sciences Publications

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