Biarylpyrimidines: a new class of ligand for high-order DNA recognition
| dc.contributor.author | Murphy, Peter M. | * |
| dc.contributor.author | Phillips, Victoria A. | * |
| dc.contributor.author | Jennings, Sharon A. | * |
| dc.contributor.author | Garbett, N.C. | * |
| dc.contributor.author | Chaires, J.B. | * |
| dc.contributor.author | Jenkins, Terence C. | * |
| dc.contributor.author | Wheelhouse, Richard T. | * |
| dc.date.accessioned | 2009-07-27T15:20:38Z | |
| dc.date.available | 2009-07-27T15:20:38Z | |
| dc.date.issued | 2003 | |
| dc.identifier.citation | Murphy PM, Phillips VA, Jennings SA, et al (2003) Biarylpyrimidines: a new class of ligand for high-order DNA recognition. Chemical Communications. 2003 (10): 1160-1161. | en |
| dc.identifier.uri | http://hdl.handle.net/10454/3145 | |
| dc.description | No | en |
| dc.description.abstract | Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase. | en |
| dc.language.iso | en | en |
| dc.relation.isreferencedby | http://dx.doi.org/10.1039/b301554h | en |
| dc.subject | Biaryl pyramidines | en |
| dc.subject | Ligands | en |
| dc.subject | DNA-recognition | en |
| dc.title | Biarylpyrimidines: a new class of ligand for high-order DNA recognition | en |
| dc.status.refereed | Yes | en |
| dc.type | Article | en |
| dc.type.version | No full-text available in the repository | en |