Biarylpyrimidines: a new class of ligand for high-order DNA recognition
Publication date
2003Author
Murphy, Peter M.Phillips, Victoria A.
Jennings, Sharon A.
Garbett, N.C.
Chaires, J.B.
Jenkins, Terence C.
Wheelhouse, Richard T.
Peer-Reviewed
YesOpen Access status
closedAccess
Metadata
Show full item recordAbstract
Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.Version
No full-text in the repositoryCitation
Murphy PM, Phillips VA, Jennings SA, et al (2003) Biarylpyrimidines: a new class of ligand for high-order DNA recognition. Chemical Communications. 2003 (10): 1160-1161.Link to Version of Record
https://doi.org/10.1039/b301554hType
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1039/b301554h