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dc.contributor.authorObrenovitch, Tihomir P.*
dc.contributor.authorChazot, P.L.*
dc.contributor.authorGodukhin, O.V.*
dc.date.accessioned2009-07-27T09:12:24Z
dc.date.available2009-07-27T09:12:24Z
dc.date.issued2002
dc.identifier.citationObrenovitch, T.P., Chazot, P.L. and Godukhin, O.V. (2002). Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors? Neuroscience Letters. Vol. 320, No. 3, pp. 161-163.en
dc.identifier.urihttp://hdl.handle.net/10454/3115
dc.descriptionNoen
dc.description.abstractIn the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study.en
dc.language.isoenen
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/S0304-3940(02)00046-0en
dc.subjectNeurogliaen
dc.subjectCentral nervous systemen
dc.subjectBrain vertebrataen
dc.subjectMammaliaen
dc.subjectRodentiaen
dc.subjectRaten
dc.subjectMouseen
dc.subjectGene expressionen
dc.subjectAstrocyteen
dc.subjectNMDA receptoren
dc.subjectCerebral cortexen
dc.subjectSpreading depressionen
dc.titleRepetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?en
dc.status.refereedYesen
dc.typeArticleen
dc.type.versionNo full-text available in the repositoryen


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