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    Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

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    Publication date
    2002
    Author
    Obrenovitch, Tihomir P.
    Chazot, P.L.
    Godukhin, O.V.
    Keyword
    Neuroglia
    Central nervous system
    Brain vertebrata
    Mammalia
    Rodentia
    Rat
    Mouse
    Gene expression
    Astrocyte
    NMDA receptor
    Cerebral cortex
    Spreading depression
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    Peer-Reviewed
    Yes
    
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    Abstract
    In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study.
    URI
    http://hdl.handle.net/10454/3115
    Version
    No full-text available in the repository
    Citation
    Obrenovitch, T.P., Chazot, P.L. and Godukhin, O.V. (2002). Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors? Neuroscience Letters. Vol. 320, No. 3, pp. 161-163.
    Link to publisher’s version
    http://dx.doi.org/10.1016/S0304-3940(02)00046-0
    Type
    Article
    Collections
    Life Sciences Publications

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