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    The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus.

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    Publication date
    2002
    Author
    Naylor, Robert J.
    Javid, Farideh A.
    Keyword
    Digestive diseases
    Internal ear disease
    ENT disease
    Nausea
    Suncus murinus
    Animal model
    Motion sickness
    Serotonine receptor
    Intraperitoneal administration
    Vomiting
    Serotonin
    Antagonist
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    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    In the present study, we investigated the effect of 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists and antagonists on motion sickness in Suncus murinus, and the possibility that the emetic stimulus of 5-HT can alter the sensitivity of the animals to the different emetic stimulus of motion sickness. 5-HT (1.0, 2.0, 4.0 and 8.0 mg/kg ip) induced emesis and that was antagonised by methysergide (1.0 mg/kg ip), the 5-HT4receptor antagonist sulphamate[1-[2-[(methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-methoxy-1H-indole-3-carboxylate (GR125487D; 1.0 mg/kg ip) and granisetron (0.5 mg/kg ip). Pretreatment with 5-HT caused a dose-related attenuation of the emetic response induced by a subsequent motion stimulus, which was not significantly modified by methysergide, granisetron or GR125487D pretreatment. (+)-1-(2,5-Dimethoxy-4-iodophenyl)-2-amino-propane (DOI; 0.5 and 1.0 mg/kg ip), 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 0.1 mg/kg ip) but not methysergide, GR125487D or granisetron, attenuated motion-induced emesis, and that was not affected by pretreatment with ketanserin (2.0 mg/kg, ip) or N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide trihydrocholoride (WAY-100635; 1.0 mg/kg ip), respectively. Indeed, ketanserin alone (0.1, 0.3, 1.0 and 2.0 mg/kg ip) attenuated motion sickness. These data indicate that 5-HT1/2, 5-HT3 and 5-HT4 receptors are involved in the induction of 5-HT-induced emesis. However, agonist action at the 5-HT1A/7 and 5-HT2 receptors, and antagonist action at the 5-HT2A receptors can attenuate motion sickness in S. murinus.
    URI
    http://hdl.handle.net/10454/3112
    Version
    No full-text available in the repository
    Citation
    Naylor, R.J. and Javid, F. (2002). The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus. Pharmacology, Biochemistry and Behavior. Vol. 73, No. 4, pp. 979-989.
    Link to publisher’s version
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0N-46MJ2JS-8&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=55e29d1ac4ad770f57e5cbfac436e446
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    Article
    Collections
    Life Sciences Publications

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