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    Imaging brain activity in conscious monkeys following oral MDMA (¿Ecstasy¿).

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    Publication date
    2006
    Author
    Harder, Josie A.
    Brevard, M.E.
    Ferris, C.F.
    Meyer, J.S.
    Keyword
    MDMA;
    Functional MRI
    Marmoset monkey
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Recreational use of 3,4-methylenedioxymethamphetamine (MDMA;¿ecstasy¿) poses worldwide potential health problems. Clinical studies show that repeated exposure to low oral doses of MDMA has toxic effects on the brain, altering cognitive and psychosocial behavior. Functional magnetic resonance imaging in conscious marmoset monkeys was used to evaluate the sensitivity of the brain to an oral dose of MDMA (1 mg/kg). Following MDMA administration, the midbrain raphe nuclei and substantia nigra, major sources of serotonin and dopamine, were activated as were the hippocampus, hypothalamus and amygdala. The corticostriatal circuit of dorsal thalamus, sensorimotor cortex and basal ganglia showed a robust, coherent activation pattern. Two key reward areas, the nucleus accumbens and prefrontal cortex, and most other cortical regions showed little activation. The visual cortex, however, showed intense activation without applied visual stimuli. These data identify brain areas and functional circuits sensitive to a recreational dose of MDMA, some of which may be vulnerable to long-term intermittent exposure to this drug.
    URI
    http://hdl.handle.net/10454/3071
    Version
    No full-text available in the repository
    Citation
    Brevard, M.E., Meyer, J.S.,Harder, J.A. and Ferris, C.F. (2006). Imaging brain activity in conscious monkeys following oral MDMA (¿Ecstasy¿). Magnetic Resonance Imaging. Vol. 24, No. 6, pp. 707-714.
    Link to publisher’s version
    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9D-4K1X5KD-2&_user=122861&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=962565051&_rerunOrigin=google&_acct=C000010080&_version=1&_urlVersion=0&_userid=122861&md5=589b6c2d9a7944b95d6dab2ff99ee8e0
    Type
    Article
    Collections
    Life Sciences Publications

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